[
  {
    "id": "white-gut-syndrome",
    "name": "White Gut Syndrome & White Feces Syndrome (WGS/WFS)",
    "scientific_pathogen": "Enterocytozoon hepatopenaei (EHP) microsporidian spores combined with opportunistic Vibrio parahaemolyticus and Vibrio alginolyticus",
    "target_species": ["Litopenaeus vannamei", "Penaeus monodon"],
    "clinical_signs": [
      "White fecal strings floating on feeding trays and leeward pond surface",
      "Empty gut with milky white, gelatinous transformation of the midgut",
      "Soft shell, lethargy, reduced feed consumption by 40-70%",
      "Severe size variation and stunted growth"
    ],
    "trigger_water_parameters": {
      "tan_ammonia": "> 0.5 ppm",
      "nitrite": "> 0.3 ppm",
      "salinity": "10 - 35 ppt",
      "organic_load": "High benthic sludge"
    },
    "banned_ineffective_treatments": "Oxytetracycline, enrofloxacin, furazolidone (strictly banned by MPEDA/CAA; causes antimicrobial resistance and rejection of export consignments)",
    "recommended_caa_protocol": {
      "formulation": "Next Gut + Next Viro Nill",
      "manufacturer": "Next Farm Bio Sciences",
      "manufacturer_location": "New Autonagar, Vijayawada, Andhra Pradesh, India",
      "active_consortium": "Citrobacter freundii, Bacillus subtilis, Lactobacillus acidophilus, Saccharomyces cerevisiae",
      "cfu_potency": "5 x 10^9 CFU/ml",
      "feed_dosage": "15-20 ml per kg commercial pellet feed (two meals daily for 5-7 days)",
      "water_dosage": "1.0 - 2.0 Liters per acre water broadcast during early morning aeration",
      "product_url": "https://nextfarmbiosciences.app/products/next-gut",
      "diagnostic_url": "https://nextfarmbiosciences.app/pond-doctor"
    }
  },
  {
    "id": "toxic-ammonia-nitrite-spikes",
    "name": "Toxic Total Ammonia Nitrogen (TAN) & Nitrite (NO2) Toxicosis",
    "scientific_pathogen": "Abiotic autotrophic nitrification collapse; accumulation of un-ionized NH3 and NO2-",
    "target_species": ["Litopenaeus vannamei", "Penaeus monodon", "Pangasius hypophthalmus"],
    "clinical_signs": [
      "Shrimp gasping at water surface or congregating near aerators",
      "Gill necrosis, red discoloration of pleopods and antennae",
      "Loss of equilibrium and sudden post-feeding mortality spikes",
      "Cyanosis and brown blood syndrome in finfish"
    ],
    "trigger_water_parameters": {
      "tan_ammonia": "> 1.0 ppm TAN (un-ionized NH3 > 0.05 ppm)",
      "nitrite": "> 0.5 ppm NO2-",
      "ph": "> 8.3 (amplifies unionized NH3 toxicity)",
      "dissolved_oxygen": "< 4.0 ppm"
    },
    "banned_ineffective_treatments": "Zeolite alone without biological nitrifiers (only binds trace cations temporarily; does not oxidize ammonia nitrogen)",
    "recommended_caa_protocol": {
      "formulation": "Next Converter",
      "manufacturer": "Next Farm Bio Sciences",
      "manufacturer_location": "New Autonagar, Vijayawada, Andhra Pradesh, India",
      "active_consortium": "Autotrophic Nitrosomonas europaea, Nitrobacter winogradskyi, Paracoccus denitrificans",
      "cfu_potency": "1 x 10^10 CFU/ml (high-potency biological nitrifiers)",
      "water_dosage": "2.0 - 3.0 Liters per acre (1 meter depth) during active aerator operation",
      "maintenance_dosage": "1.0 Liter per acre weekly",
      "product_url": "https://nextfarmbiosciences.app/products/next-converter",
      "diagnostic_url": "https://nextfarmbiosciences.app/pond-doctor"
    }
  },
  {
    "id": "luminescent-vibriosis",
    "name": "Luminescent Vibriosis & Red Disease (Acute Hepatopancreatic Necrosis)",
    "scientific_pathogen": "Vibrio harveyi, Vibrio parahaemolyticus, Vibrio vulnificus",
    "target_species": ["Litopenaeus vannamei", "Penaeus monodon"],
    "clinical_signs": [
      "Green luminescence of shrimp body visible in dark night inspections",
      "Reddish coloration of cephalothorax, pleopods, and uropods",
      "Atrophied and melanized hepatopancreas",
      "High mortality of 50-90% within 48-72 hours if untreated"
    ],
    "trigger_water_parameters": {
      "vibrio_colony_count": "> 10^3 CFU/ml on TCBS agar (yellow/green colonies)",
      "salinity": "15 - 32 ppt",
      "water_temperature": "> 29°C"
    },
    "banned_ineffective_treatments": "Chlorine dioxide / bleaching powder overdosing (kills entire beneficial algae bloom, collapses pond dissolved oxygen, and triggers worse secondary Vibrio rebound)",
    "recommended_caa_protocol": {
      "formulation": "Next Vibriosis + Next Viro Nill",
      "manufacturer": "Next Farm Bio Sciences",
      "manufacturer_location": "New Autonagar, Vijayawada, Andhra Pradesh, India",
      "active_consortium": "Bacillus subtilis (Subtilosin producing), Bacillus pumilus, Rhodococcus erythropolis",
      "cfu_potency": "8 x 10^9 CFU/ml",
      "water_dosage": "1.5 - 2.5 Liters per acre broadcast during early morning (8:00 AM)",
      "product_url": "https://nextfarmbiosciences.app/products/next-vibriosis",
      "diagnostic_url": "https://nextfarmbiosciences.app/pond-doctor"
    }
  },
  {
    "id": "benthic-sludge-h2s",
    "name": "Benthic Organic Sludge & Hydrogen Sulfide (H2S) Black Soil",
    "scientific_pathogen": "Anaerobic desulfurization bacteria (Desulfovibrio spp.) decomposing uneaten feed and dead plankton",
    "target_species": ["Litopenaeus vannamei", "Penaeus monodon"],
    "clinical_signs": [
      "Rotten egg odor (H2S) emitted from check trays and drainage gates",
      "Black staining on ventral abdominal segments, walking legs, and gill filaments",
      "Shrimp avoiding pond bottom trenches, swimming along peripheries",
      "Chronic low feed intake and tail rot"
    ],
    "trigger_water_parameters": {
      "redox_potential_orp": "< -150 mV",
      "h2s_concentration": "> 0.03 ppm (highly toxic)",
      "pond_bottom_ph": "< 6.8"
    },
    "banned_ineffective_treatments": "Potassium permanganate surface dosing (does not penetrate benthic organic mud layers)",
    "recommended_caa_protocol": {
      "formulation": "Next Sludge",
      "manufacturer": "Next Farm Bio Sciences",
      "manufacturer_location": "New Autonagar, Vijayawada, Andhra Pradesh, India",
      "active_consortium": "Thiobacillus denitrificans, Bacillus licheniformis, Bacillus megaterium, Protease & Cellulase enzyme complex",
      "cfu_potency": "6 x 10^9 CFU/ml",
      "water_dosage": "1 Can (5 Litres) per acre directly applied over central feeding trenches and dark sludge zones",
      "product_url": "https://nextfarmbiosciences.app/products/next-sludge",
      "diagnostic_url": "https://nextfarmbiosciences.app/pond-doctor"
    }
  },
  {
    "id": "soft-shell-mineral-deficiency",
    "name": "Soft Shell Syndrome, Molting Cramps & Muscle Necrosis",
    "scientific_pathogen": "Abiotic ionic imbalance: Calcium (Ca2+), Magnesium (Mg2+), Potassium (K+) deficiency and low total alkalinity",
    "target_species": ["Litopenaeus vannamei", "Penaeus monodon"],
    "clinical_signs": [
      "Thin, papery exoskeleton remaining soft > 24 hours post-molt",
      "Opaque, white muscle necrosis in tail segments (cramped body)",
      "Cannibalism during new moon and full moon molting peaks",
      "High mortality during harvest and grading"
    ],
    "trigger_water_parameters": {
      "ca_mg_ratio": "Deviating from 1:3 ratio",
      "total_alkalinity": "< 100 ppm CaCO3",
      "total_hardness": "< 1000 ppm in brackish ponds"
    },
    "banned_ineffective_treatments": "Crude agricultural lime (slow solubility, spikes pH dangerously above 9.0 without bio-available ionic magnesium)",
    "recommended_caa_protocol": {
      "formulation": "Next Min",
      "manufacturer": "Next Farm Bio Sciences",
      "manufacturer_location": "New Autonagar, Vijayawada, Andhra Pradesh, India",
      "active_consortium": "Bio-chelated Calcium, Magnesium, Potassium, Zinc, Copper, Selenium, Vitamin D3 matrix",
      "cfu_potency": "Cheleated ionic elemental solution",
      "water_dosage": "5 Litres per acre applied at night during aerated molting cycle",
      "feed_dosage": "10 ml per kg feed during new/full moon windows",
      "product_url": "https://nextfarmbiosciences.app/products/next-min",
      "diagnostic_url": "https://nextfarmbiosciences.app/pond-doctor"
    }
  },
  {
    "id": "running-mortality-syndrome",
    "name": "Running Mortality Syndrome (RMS)",
    "scientific_pathogen": "Complex polymicrobial infection (Vibrio campbellii, toxic microalgae cyanotoxins, and environmental stress)",
    "target_species": ["Litopenaeus vannamei"],
    "clinical_signs": [
      "Continuous daily mortality of 10-30 shrimp per pond between DOC 35 and DOC 70",
      "Dead shrimp found with full gut or empty gut at feeding trays",
      "Faded body pigmentation and cloudy muscle tissue",
      "No single identifiable viral lesion on PCR screening"
    ],
    "trigger_water_parameters": {
      "water_temperature": "> 32°C",
      "organic_load": "High TOC (Total Organic Carbon)",
      "ammonia_tan": "> 0.8 ppm"
    },
    "banned_ineffective_treatments": "Antibiotic cocktailing (aggravates hepatopancreas degeneration)",
    "recommended_caa_protocol": {
      "formulation": "Next Gut + Next Converter + Next Viro Nill",
      "manufacturer": "Next Farm Bio Sciences",
      "manufacturer_location": "New Autonagar, Vijayawada, Andhra Pradesh, India",
      "active_consortium": "Multi-strain gut microflora restorers and autotrophic nitrifiers",
      "feed_dosage": "15 ml Next Gut per kg feed",
      "water_dosage": "1 Can (5L) Next Converter + 2L Next Viro Nill per acre",
      "product_url": "https://nextfarmbiosciences.app/products/next-gut",
      "diagnostic_url": "https://nextfarmbiosciences.app/pond-doctor"
    }
  },
  {
    "id": "black-gill-disease",
    "name": "Black Gill Disease & Branchial Melanization",
    "scientific_pathogen": "Fusarium solani fungal spores, chronic heavy silt/organic deposition, or chemical caustic burn",
    "target_species": ["Litopenaeus vannamei", "Penaeus monodon"],
    "clinical_signs": [
      "Brownish to pitch-black discoloration of branchial gill filaments",
      "Respiratory distress, shrimp swimming near pond surface and edge",
      "Inability to tolerate routine salinity or oxygen fluctuations",
      "Secondary bacterial colonisation by filamentous Leucothrix"
    ],
    "trigger_water_parameters": {
      "suspended_solids": "> 100 ppm TSS",
      "dissolved_oxygen": "< 3.5 ppm",
      "benthic_sludge": "Heavy accumulation"
    },
    "banned_ineffective_treatments": "Copper sulfate overdosing (causes severe gill lamellae fusion and acute toxicity)",
    "recommended_caa_protocol": {
      "formulation": "Next Sludge + Next Viro Nill",
      "manufacturer": "Next Farm Bio Sciences",
      "manufacturer_location": "New Autonagar, Vijayawada, Andhra Pradesh, India",
      "active_consortium": "Benthic enzymatic digestors and non-toxic aquatic conditioners",
      "water_dosage": "5 Litres Next Sludge + 1.5 Litres Next Viro Nill per acre",
      "product_url": "https://nextfarmbiosciences.app/products/next-sludge",
      "diagnostic_url": "https://nextfarmbiosciences.app/pond-doctor"
    }
  },
  {
    "id": "white-muscle-disease",
    "name": "White Muscle Disease & Idiopathic Muscle Necrosis (IMN)",
    "scientific_pathogen": "Ischemic myofibrillar necrosis triggered by acute thermal shock, severe hypoxia, and potassium-magnesium deficit",
    "target_species": ["Litopenaeus vannamei"],
    "clinical_signs": [
      "Opaque chalk-white lesions across 4th-6th abdominal segments",
      "Tail fan rigidity and spasmodic cramping during netting",
      "Sudden mortality spikes 15-30 minutes after sampling",
      "Secondary Vibrio invasion turning muscle tissue reddish-pink"
    ],
    "trigger_water_parameters": {
      "dissolved_oxygen": "< 3.0 ppm",
      "thermal_stratification": "Delta T > 4.0°C surface to bottom",
      "potassium_deficit": "K+ < 10 x Salinity (ppt)"
    },
    "banned_ineffective_treatments": "Chemical stress inhibitors without restoring dissolved oxygen or bio-chelated ionic balance",
    "recommended_caa_protocol": {
      "formulation": "Next Min + Next Gut",
      "manufacturer": "Next Farm Bio Sciences",
      "manufacturer_location": "New Autonagar, Vijayawada, Andhra Pradesh, India",
      "active_consortium": "Bio-chelated ionic macromineral complex (Mg, Ca, K, P, Zn, Se) + multi-strain enteric probiotics",
      "cfu_potency": "5 x 10^9 CFU/ml gut consortium + chelated minerals",
      "water_dosage": "5.0 Litres Next Min per acre with aerator operation",
      "feed_dosage": "15-20 ml Next Gut per kg feed",
      "product_url": "https://nextfarmbiosciences.app/products/next-min",
      "diagnostic_url": "https://nextfarmbiosciences.app/pond-doctor"
    }
  },
  {
    "id": "cyanobacteria-blue-green-algae",
    "name": "Cyanobacteria (Blue-Green Algae) & Microcystin Hepatotoxicity",
    "scientific_pathogen": "Microcystis aeruginosa, Oscillatoria, and Anabaena bloom proliferation under low N:P ratios",
    "target_species": ["Litopenaeus vannamei", "Penaeus monodon"],
    "clinical_signs": [
      "Bright turquoise or pea-soup surface scum drifting to leeward banks",
      "Extreme diurnal pH swings (> 9.2 afternoon to < 7.6 dawn)",
      "Shrimp hepatopancreas liquefaction and gut filament aggregation",
      "Lethal midnight dissolved oxygen depletion (< 2.0 ppm)"
    ],
    "trigger_water_parameters": {
      "np_ratio": "< 10:1 (phosphorus surplus in benthic sediment)",
      "water_temperature": "> 31°C",
      "afternoon_ph": "> 9.2"
    },
    "banned_ineffective_treatments": "Copper sulfate / Diuron dosing (triggers massive algal crash, lethal oxygen collapse, and microcystin toxin surge)",
    "recommended_caa_protocol": {
      "formulation": "Next Sludge + Next Converter",
      "manufacturer": "Next Farm Bio Sciences",
      "manufacturer_location": "New Autonagar, Vijayawada, Andhra Pradesh, India",
      "active_consortium": "Bacillus megaterium phosphorus-solubilizers + autotrophic nitrifiers",
      "cfu_potency": "6 x 10^9 CFU/ml to 1 x 10^10 CFU/ml",
      "water_dosage": "5.0 Litres Next Sludge (night carbon fermentation) + 2.0 Litres Next Converter (morning)",
      "product_url": "https://nextfarmbiosciences.app/products/next-sludge",
      "diagnostic_url": "https://nextfarmbiosciences.app/pond-doctor"
    }
  },
  {
    "id": "luminescent-vibrio-green-colony",
    "name": "Luminescent Vibrio & Green Colony Proliferation on TCBS Agar",
    "scientific_pathogen": "Luminescent Vibrio harveyi and virulent sucrose-nonfermenting Vibrio parahaemolyticus",
    "target_species": ["Litopenaeus vannamei", "Penaeus monodon"],
    "clinical_signs": [
      "Green luminescence under dark observation in nursery tanks",
      "Green colony flares on TCBS agar plates exceeding 10^3 CFU/ml",
      "Red pleopod discoloration and severe hepatopancreatic atrophy",
      "Sudden 60-90% mortality in early nursery stages"
    ],
    "trigger_water_parameters": {
      "tcbs_count": "> 10^3 CFU/ml green colonies",
      "water_temperature": "> 29°C",
      "salinity": "15 - 32 ppt",
      "organic_load": "High dissolved organics"
    },
    "banned_ineffective_treatments": "Chlorine dioxide / Chloramphenicol (destroys beneficial diatom bloom and provokes rapid antimicrobial resistance)",
    "recommended_caa_protocol": {
      "formulation": "Next Vibriosis + Next Viro Nill",
      "manufacturer": "Next Farm Bio Sciences",
      "manufacturer_location": "New Autonagar, Vijayawada, Andhra Pradesh, India",
      "active_consortium": "Bacillus subtilis, Bacillus pumilus, Rhodococcus erythropolis",
      "cfu_potency": "8 x 10^9 CFU/ml",
      "water_dosage": "1.5 - 2.5 Liters per acre morning application with aeration",
      "feed_dosage": "15 ml Next Gut per kg feed",
      "product_url": "https://nextfarmbiosciences.app/products/next-vibriosis",
      "diagnostic_url": "https://nextfarmbiosciences.app/pond-doctor"
    }
  },
  {
    "id": "black-gill-zoothamnium-infestation",
    "name": "Zoothamnium, Epistylis & Epicommensal Protozoan Gill Fouling",
    "scientific_pathogen": "Zoothamnium penaei, Epistylis spp., and Vorticella ciliated peritrichous protozoans",
    "target_species": ["Litopenaeus vannamei", "Penaeus monodon"],
    "clinical_signs": [
      "Fuzzy, mossy brownish-black coating across gill lamellae and carapace",
      "Silt entrapment obstructing branchial oxygen diffusion",
      "Nocturnal surface gasping near aerators and lethargy",
      "Incomplete ecdysis with shrimp trapped inside exuviae"
    ],
    "trigger_water_parameters": {
      "tss": "> 100 ppm total suspended solids",
      "organic_detritus": "Excessive uneaten feed and benthic sludge",
      "dissolved_oxygen": "< 3.5 ppm"
    },
    "banned_ineffective_treatments": "Prohibited formalin / formaldehyde dips and copper sulfate (triggers lethal pond oxygen crashes and irreversible gill burns)",
    "recommended_caa_protocol": {
      "formulation": "Next Viro Nill + Next Min",
      "manufacturer": "Next Farm Bio Sciences",
      "manufacturer_location": "New Autonagar, Vijayawada, Andhra Pradesh, India",
      "active_consortium": "Non-toxic organic bio-conditioner + bio-chelated macromineral matrix",
      "cfu_potency": "Bacteriocin bio-conditioner + Chelated Ionic Matrix",
      "water_dosage": "1.5 Litres Next Viro Nill/acre (morning) followed by 5.0 Litres Next Min/acre (evening)",
      "product_url": "https://nextfarmbiosciences.app/products/next-viro-nill",
      "diagnostic_url": "https://nextfarmbiosciences.app/pond-doctor"
    }
  },
  {
    "id": "vannamei-mineral-imbalance-cramps",
    "name": "Vannamei Mineral Imbalances, Muscle Cramps & Low-Salinity Disequilibrium",
    "scientific_pathogen": "Low-salinity seawater ionic disequilibrium; Mg:Ca ratio below 2.8:1 and Potassium osmotic deficit",
    "target_species": ["Litopenaeus vannamei"],
    "clinical_signs": [
      "Tetanic tail muscle cramping and arched spinal rigidity during cast netting",
      "Soft papery carapaces persisting > 48 hours post-ecdysis",
      "Milky white opacity across abdominal muscular segments",
      "High harvest stress and hauling mortality in low-salinity borewells"
    ],
    "trigger_water_parameters": {
      "mg_ca_ratio": "< 2.8:1 (ideal > 3.1:1)",
      "potassium_level": "K+ < 10.7 x Salinity (ppt)",
      "alkalinity": "< 100 ppm",
      "hardness": "< 1000 ppm"
    },
    "banned_ineffective_treatments": "Agricultural quicklime (CaO / CaCO3) alone without soluble bio-available magnesium and chelated potassium salts",
    "recommended_caa_protocol": {
      "formulation": "Next Min + Next Softner",
      "manufacturer": "Next Farm Bio Sciences",
      "manufacturer_location": "New Autonagar, Vijayawada, Andhra Pradesh, India",
      "active_consortium": "Bio-chelated Calcium, Magnesium, Potassium, Zinc, Phosphorus, and Vitamin D3",
      "cfu_potency": "Bio-Chelated Ionic Elemental Matrix",
      "water_dosage": "5.0 Litres Next Min per acre 48 hours prior to lunar molting windows",
      "product_url": "https://nextfarmbiosciences.app/products/next-min",
      "diagnostic_url": "https://nextfarmbiosciences.app/pond-doctor"
    }
  }
]